Chronic, supra-physiological doses of nandrolone decanoate and exercise induced cardio-toxicity in an animal-model study
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چکیده
منابع مشابه
Chronic Administration of High Doses of Nandrolone Decanoate on the Pituitary-Gonadal Axis in Male Rats
BACKGROUND Anabolic-androgenic steroids (AAS) are abused by athletes. OBJECTIVES The present study was designed to evaluate chronic administration of high doses of nandrolone decanoate (ND) on the pituitary-gonadal axis and hematological parameters in normal male rats. MATERIALS AND METHODS Thirty Wistar-Albino male rats were divided assigned to control (C), placebo (P) and test (T) groups ...
متن کاملNandrolone Decanoate, Behaviour and Brain: Animal Experimental Studies
Abuse of anabolic androgenic steroids (AAS) has been linked to psychiatric and physiological complications in humans. Studies have further found a relationship between AAS abuse and abuse of alcohol and other drugs. The main objective of this animal experimental thesis was to examine to what extent the AAS compound nandrolone decanoate (ND; Deca-Durabol [15 mg/kg/day for 2 weeks]) induces behav...
متن کاملThe role of neuropeptide-Y in nandrolone decanoate-induced attenuation of antidepressant effect of exercise
Since the increased prevalence of anabolic androgenic steroids abuse in last few decades is usually accompanied by various exercise protocols, the scope of our study was to evaluate the effects of chronic nandrolone decanoate administration in supraphysiological dose and a prolonged swimming protocol (alone and simultaneously with nandrolone decanoate) on depressive state in male rats. Simultan...
متن کاملchronic administration of high doses of nandrolone decanoate on the pituitary-gonadal axis in male rats
conclusions chronic administration of high doses of nd can alter serum fsh, lh and testosterone and hematological parameters in male rats. results serum testosterone, lh, fsh, weight gain, food and water intake in group t were significantly decreased compared to other groups (p < 0.05). in addition erythrocyte, leucocytes, hemoglobin and hematocrit in group t were significantly increased compar...
متن کاملHeart Reaction to Nandrolone Decanoate plus Two Different Intensities of Endurance Exercise: Electrocardiography and Stereological Approach
Background: Regarding the negative effects of androgenic anabolic steroids (AASs) abuse, the long-term effect of nandrolone decanoate with/without two intensities of endurance exercise training was investigated on heart tissue and electrocardiogram (ECG) in rats. Methods: The experiment was conducted on 63 male Wistar rats, which were 4 months old. The rats were divide into groups of control (C...
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ژورنال
عنوان ژورنال: Acta Physiologica
سال: 2013
ISSN: 1748-1708
DOI: 10.1111/apha.12093